C5 antibody

Catalog No. ABIN576124

Product Details anti-C5 Antibody

Target: C5 (Complement Component 5 (C5))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This C5 antibody is un-conjugated

Application: Immunodiffusion (ID)

Specificity: Recognizes complement component 5 (C5), a member of the complement system. The complement system consists of a tightly regulated network of proteins. Its activation leads to a sequential cascade of enzymatic reactions, resulting in opsonisation of the pathogens and their removal by phagocytes, as well as cell lysis. Three pathways have been described, the antibody-dependent pathway (classical pathway), the alternative pathway and the lectin activation pathway. The complement system plays a critical role in both innate and adaptive immune responses. It is also involved in tissue regeneration, tumor growth and some human pathologies. Complement component 5 is the initiator of the effector terminal phase of the complement system. C5 convertase cleaves C5 into C5a, a potent anaphylatoxin, and C5b, ultimately resulting in the formation of the multimeric membrane attack complex (MAC) together with the other components of the terminal pathway (C5b-C9). Gives a single arc when tested by immunoelectrophoresis (IEP) against human plasma. The identity has been confirmed by double diffusion against fresh human plasma and a known anti human C5.

Purification: Ion exchange chromatography

Immunogen: Human C5, purified from plasma.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Glycine buffered saline,  pH 7.4, 0.09 % sodium azide, 0.1 % EACA, 0.01 % benzamidine, 1 mM EDTA.

Preservative: Sodium azide, Benzamidine, EACA

Precaution of Use: This product contains Benzamidine and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: Complement C5 (C5 Products)

Synonyms: C5 antibody, LOC565774 antibody, C5a antibody, C5b antibody, CPAMD4 antibody, Hc antibody, RGD1561905 antibody, He antibody, complement C5 antibody, complement component 5 antibody, hemolytic complement antibody, C5 antibody, c5 antibody, Hc antibody

Background: Name/Gene ID: C5

Synonyms: C5, Anaphylatoxin C5a analog, CPAMD4, Complement C5, Complement component 5

Gene ID: 727

UniProt: P01031

Pathways: Complement System, Carbohydrate Homeostasis