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Caspase 1 antibody (Cleaved-Asp210)
CASP1
Reactivity: Human
WB, ELISA, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Caspase 1 Antibody
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Target
See all Caspase 1 (CASP1) Antibodies
Caspase 1 (CASP1)
Binding Specificity
All epitopes for Caspase 1 antibodies
Cleaved-Asp210
Reactivity
All reactivities for Caspase 1 antibodies
Human
Host
All hosts for Caspase 1 antibodies
Rabbit
Clonality
All clonalities for Caspase 1 antibodies
Polyclonal
Conjugate
All conjugates for Caspase 1 antibodies
This Caspase 1 antibody is un-conjugated
Application
All applications for Caspase 1 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificity
CASP-1,CASP1,CASP1,Caspase 1,Caspase-1 subunit p10,ICE,IL-1 beta-converting enzyme,IL-1BC,IL1 beta converting enzyme,IL1B convertase,Interleukin 1 beta convertase,Interleukin 1B converting enzyme,Interleukin-1 beta convertase,Interleukin-1 beta-converting enzyme,p45
Purification
Affinity purification
Immunogen
Synthesized peptide derived from the Internal region of human Caspase-1
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for Caspase 1
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Target
Caspase 1 (CASP1)
Alternative Name
CASP1 (CASP1 Products )
Synonyms
ICE antibody, IL1BC antibody, P45 antibody, Il1bc antibody, Ice antibody, CASP1 antibody, CG5370 antibody, DCP-1 antibody, DCP1 antibody, Dcp1 antibody, Dmel\\CG5370 antibody, ccp1 antibody, dcp-1 antibody, dcp1 antibody, l(2)01862 antibody, l(2)02132 antibody, caspase 1 antibody, caspase 1, apoptosis-related cysteine peptidase antibody, caspase 4, apoptosis-related cysteine peptidase antibody, Death caspase-1 antibody, caspase-1 antibody, caspase antibody, caspase recruitment domain-containing protein 16 antibody, caspase 4 antibody, CASP1 antibody, Casp1 antibody, CASP4 antibody, Dcp-1 antibody, Caspase1 antibody, LOC5564196 antibody, LOC451519 antibody
Background
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Molecular Weight
45kDa
Gene ID
834
UniProt
P29466
Pathways
Apoptosis , Interferon-gamma Pathway , Positive Regulation of Endopeptidase Activity , Inflammasome
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