DCC antibody (Internal Region)

Catalog No. ABIN5956357

Product Details anti-DCC Antibody

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: Colorectal cancer related chromosome sequence 18,Colorectal cancer suppressor,CRC 18,CRC18,CRCR 1,CRCR1,DCC,DCC,Deleted in colorectal cancer protein,Deleted in colorectal carcinoma,Immunoglobulin superfamily DCC subclass member 1,Netrin receptor DCC,Tumor suppressor protein DCC

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the Internal region of human DCC

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DCC

Target: DCC (Deleted in Colorectal Carcinoma (DCC))

Alternative Name: DCC (DCC Products)

Synonyms: CRC18 antibody, CRCR1 antibody, IGDCC1 antibody, MRMV1 antibody, DCC antibody, zdcc antibody, C030036D22Rik antibody, Igdcc1 antibody, xdcc antibody, XDCCa antibody, dcca-A antibody, Dcc antibody, DCC netrin 1 receptor antibody, deleted in colorectal carcinoma antibody, netrin receptor DCC antibody, DCC antibody, dcc antibody, Dcc antibody, LOC100712666 antibody

Background: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Molecular Weight: 158kDa

Gene ID: 1630

UniProt: P43146

Pathways: Regulation of Cell Size