Neuregulin 1 antibody

Catalog No. ABIN5957266

Product Details anti-Neuregulin 1 Antibody

Target: Neuregulin 1 (NRG1)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Acetylcholine receptor-inducing activity,Acetylcholine receptor-inducing activity,CHICK,homolog of,ARIA,Breast cancer cell differentiation factor p45,GGF,GGF2,Glial growth factor,Heregulin,heregulin,alpha (45kD,ERBB2 p185-activator),HGL,HRG,HRG1,HRGA,MST131,NDF,Neu differentiation factor,Neuregulin 1,neuregulin 1 type IV beta 1a,neuregulin 1 type IV beta 3,Neuregulin-1,NRG 1,nrg1,NRG1-IT2,NRG1,OTTHUMP00000225398,OTTHUMP00000225419,OTTHUMP00000225420,OTTHUMP00000225421,OTTHUMP00000225422,OTTHUMP00000225477,OTTHUMP00000225545,OTTHUMP00000230603,OTTHUMP00000230605,pro-neuregulin-1,membrane-bound isoform,Pro-NRG1,ProNRG1,Sensory and motor neuron-derived factor,SMDF

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the N-terminal region of human Neuregulin-1.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: Neuregulin-1 (NRG1 Products)

Synonyms: 6030402G23Rik antibody, ARIA antibody, D230005F13Rik antibody, GGF antibody, GGFII antibody, HRG antibody, HRGalpha antibody, Hgl antibody, NDF antibody, SMDF antibody, GGF2 antibody, HGL antibody, HRG1 antibody, HRGA antibody, MST131 antibody, NRG-1 antibody, heregulin antibody, nrg1-A antibody, pro-neuregulin-1 antibody, NRG1 antibody, wu:fm70e01 antibody, DKFZp459A1838 antibody, neuregulin 1 antibody, histidine rich glycoprotein antibody, neuregulin 1 L homeolog antibody, Nrg1 antibody, NRG1 antibody, HRG antibody, nrg1.L antibody, nrg1 antibody

Background: The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).

Molecular Weight: 70kDa

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation