CMA1 antibody

Catalog No. ABIN5958200

Product Details anti-CMA1 Antibody

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Alpha-chymase,Chymase 1,Chymase 1 mast cell,chymase 1 preproprotein transcript E,chymase 1 preproprotein transcript I,Chymase,Chymase,heart,Chymase,mast cell,CMA1,CMA1,CYH,CYM,EC 3.4.21.39,Mast cell chymase 1,Mast cell protease 3,Mast cell protease 5,Mast cell protease I,Mast cell protease III,Mcp-5,MCP3P,Mcpt5,MCT1,MGC119890,MGC119891,MMCP-5

Purification: Affinity purification

Immunogen: Synthesized peptide derived from the Internal region of human Chymase.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CMA1

Target: CMA1 (Chymase 1, Mast Cell (CMA1))

Alternative Name: Chymase (CMA1 Products)

Synonyms: CYH antibody, MCT1 antibody, chymase antibody, MMCP-5 antibody, Mcp-5 antibody, Mcp5 antibody, Mcpt5 antibody, MCP3P antibody, CMA1 antibody, Chymase antibody, chymase 1 antibody, chymase 1, mast cell antibody, chymase-like antibody, CMA1 antibody, Cma1 antibody, LOC100008644 antibody

Background: This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.CMA1 (Chymase 1) is a Protein Coding gene. Diseases associated with CMA1 include Urticaria Pigmentosa and Urticaria. Among its related pathways are Degradation of the extracellular matrix and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. GO annotations related to this gene include serine-type endopeptidase activity and peptide binding. An important paralog of this gene is GZMB.

Molecular Weight: 27kDa

Gene ID: 1215

UniProt: P23946

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis