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GRK2 antibody
ADRBK1
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-GRK2 Antibody
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Target
See all GRK2 (ADRBK1) Antibodies
GRK2 (ADRBK1)
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Reactivity
All reactivities for GRK2 antibodies
Human, Mouse, Rat
Host
All hosts for GRK2 antibodies
Rabbit
Clonality
All clonalities for GRK2 antibodies
Polyclonal
Conjugate
All conjugates for GRK2 antibodies
This GRK2 antibody is un-conjugated
Application
All applications for GRK2 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
ADRBK1,Adrenergic beta receptor kinase 1,ARBK1,BARK,BARK1,Beta adrenergic receptor kinase 1,Beta ARK 1,Beta ARK1,Beta-adrenergic receptor kinase 1,Beta-ARK-1,FLJ16718,G protein coupled receptor kinase 2,G-protein coupled receptor kinase 2,GRK2
Purification
Affinity purification
Immunogen
Synthesized peptide derived from the C-terminal region of human GRK 2
Isotype
IgG
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Discover our top product ADRBK1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Restrictions
For Research Use only
Handling
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Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol pH 7.4.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for GRK2
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Target
GRK2 (ADRBK1)
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Alternative Name
GRK 2 (ADRBK1 Products )
Synonyms
Adrbk-1 antibody, Bark-1 antibody, GRK2 antibody, betaARK1 antibody, BARK1 antibody, BETA-ARK1 antibody, GRK-2 antibody, Grk2 antibody, beta-adrenergic receptor kinase 1 antibody, G protein-coupled receptor kinase 2 antibody, Tsp_00497 antibody, grk2 antibody, Grk2 antibody, GRK2 antibody
Background
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Molecular Weight
80kDa
Gene ID
156
UniProt
P25098
Pathways
EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of G-Protein Coupled Receptor Protein Signaling , CXCR4-mediated Signaling Events , G-protein mediated Events , Interaction of EGFR with phospholipase C-gamma , Thromboxane A2 Receptor Signaling
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