Merlin antibody

Catalog No. ABIN5963764

Product Details anti-Merlin Antibody

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human NF2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: NF2 (NF2 Products)

Synonyms: ACN antibody, BANF antibody, SCH antibody, NF2 antibody, merlin antibody, zgc:194620 antibody, zgc:194631 antibody, NF2a antibody, nf2 antibody, neurofibromin 2 antibody, neurofibromin 2a (merlin) antibody, neurofibromin 2b (merlin) antibody, neurofibromin 2 (merlin) S homeolog antibody, NF2 antibody, Nf2 antibody, nf2a antibody, nf2b antibody, nf2.S antibody

Background:

Synonyms: ACN,BANF,Bilateral acoustic neuroma,MERL,Merlin,Moesin ezrin radixin like protein,Moesin ezrin radizin like,Moesin-ezrin-radixin-like protein,Neurofibromatosis 2,Neurofibromatosis type 2,Neurofibromatosis2,Neurofibromin 2,Neurofibromin-2,Neurofibromin2,NF 2,Nf2,SCH,Schwannomerlin,Schwannomin

Background: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Molecular Weight:

Observed_MW: 72kDa

Calculated_MW: 19-30kDa/59-72kDa

Gene ID: 4771

UniProt: P35240

Pathways: Cell-Cell Junction Organization