Nibrin antibody

Catalog No. ABIN5963855

Product Details anti-Nibrin Antibody

Target: Nibrin (NBN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nibrin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human NBN

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Nibrin

Target: Nibrin (NBN)

Alternative Name: NBN (NBN Products)

Synonyms: NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody

Background:

Synonyms: AT V1,AT V2,ATV,Cell cycle regulatory protein p95,FLJ10155,MGC87362,Nbn,NBN,NBS 1,NBS,NBS1,Nibrin,Nijmegen breakage syndrome 1 (nibrin),Nijmegen breakage syndrome,Nijmegen breakage syndrome protein 1,p95,p95 protein of the MRE11/RAD50 complex

Background: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Molecular Weight:

Observed_MW: 95kDa

Calculated_MW: 84kDa

Gene ID: 4683

UniProt: O60934

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response