PLAT antibody

Catalog No. ABIN5964215

Product Details anti-PLAT Antibody

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAT antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human PLAT

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Alternative Name: PLAT (PLAT Products)

Synonyms: T-PA antibody, TPA antibody, AU020998 antibody, AW212668 antibody, D8Ertd2e antibody, tPA antibody, PATISS antibody, tpa antibody, Plat antibody, plat antibody, t-pa antibody, plasminogen activator, tissue type antibody, plasminogen activator, tissue antibody, chromosome 20 open reading frame 181 antibody, plasminogen activator, tissue L homeolog antibody, PLAT antibody, Plat antibody, plat antibody, C20orf181 antibody, plat.L antibody

Background:

Synonyms: Alteplase,DKFZp686I03148,Plasminogen activator tissue,Plasminogen activator tissue type,PLAT,Reteplase,t PA,T Plasminogen Activator,t-PA,T-plasminogen activator,Tissue plasminogen activator (t PA),Tissue type plasminogen activator,Tissue-type plasminogen activator chain B,tPA,TPA,TPA1

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight:

Observed_MW: 63kDa

Calculated_MW: 32kDa/44kDa/57kDa/62kDa

Gene ID: 5327

UniProt: P00750

Pathways: Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome