MCM4 antibody

Catalog No. ABIN5964999

Product Details anti-MCM4 Antibody

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human MCM4

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MCM4

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Alternative Name: MCM4 (MCM4 Products)

Synonyms: cdc21 antibody, CDC21 antibody, CDC54 antibody, NKCD antibody, NKGCD antibody, P1-CDC21 antibody, hCdc21 antibody, 19G antibody, AI325074 antibody, AU045576 antibody, Cdc21 antibody, Mcmd4 antibody, mKIAA4003 antibody, mcdc21 antibody, cb1025 antibody, fc12c09 antibody, fj85g09 antibody, hm:zeh1616 antibody, wu:fc12c09 antibody, wu:fj85g09 antibody, zeh1616 antibody, minichromosome maintenance complex component 4 L homeolog antibody, minichromosome maintenance complex component 4 S homeolog antibody, minichromosome maintenance complex component 4 antibody, mcm4.L antibody, mcm4.S antibody, MCM4 antibody, mcm4 antibody, Mcm4 antibody

Background:

Synonyms: 19G,AI325074,AU045576,CDC 21,CDC 54,CDC21,CDC21 homolog,CDC21,S. pombe,homolog of,CDC54,Cell division cycle 21,S. pombe,homolog of,DNA replication licensing factor MCM 4,DNA replication licensing factor MCM4,hCdc 21,hCdc21,Homolog of S. pombe cell devision cycle 21,KIAA4003,mcdc21,MCM 4,MCM 4 minichromosome maintenance deficient 4,mcm4,MCM4 minichromosome maintenance deficient 4,MCM4 minichromosome maintenance deficient 4,mitotin (S. cerevisiae),MCM4,Mcmd4,MGC33310,Minichromosome maintenance 4,Minichromosome maintenance complex component 4,Minichromosome maintenance deficient (S. cerevisiae) 4,Minichromosome maintenance deficient 4,Minichromosome maintenance deficient 4 homolog (S. cerevisiae),Minichromosome maintenance,S. cerevisiae,homolog of,4,mKIAA4003,NKCD,NKGCD,P1 CDC21,P1-CDC21,P1CDC21

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Molecular Weight:

Observed_MW: 110kDa

Calculated_MW: 96kDa

Gene ID: 4173

UniProt: P33991

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA