CTLA4 antibody

Catalog No. ABIN5965371

Product Details anti-CTLA4 Antibody

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human CTLA4

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CD152 (CTLA4 Products)

Synonyms: CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody

Background:

Synonyms: ALPS5,CD 152,CD,CD152,CD152 antigen,CD152 isoform,Celiac disease 3,CELIAC3,CTLA 4,CTLA-4,CTLA4,CTLA4,Cytotoxic T cell associated 4,Cytotoxic T lymphocyte antigen 4,Cytotoxic T lymphocyte associated 4,Cytotoxic T lymphocyte associated 4,soluble isoform,included,Cytotoxic T lymphocyte associated antigen 4,Cytotoxic T lymphocyte associated antigen 4 short spliced form,Cytotoxic T lymphocyte associated protein 4,Cytotoxic T lymphocyte associated serine esterase 4,Cytotoxic T lymphocyte protein 4,Cytotoxic T-lymphocyte protein 4,Cytotoxic T-lymphocyte-associated antigen 4,GRD4,GSE,ICOS,IDDM12,insulin-dependent diabetes mellitus 12,Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4,OTTHUMP00000216623

Background: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Molecular Weight:

Observed_MW: 48kDa

Calculated_MW: 6kDa/8kDa/19kDa/24kDa

Gene ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints