RFC2 antibody

Catalog No. ABIN5967649

Product Details anti-RFC2 Antibody

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFC2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human RFC2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RFC2

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Alternative Name: RFC2 (RFC2 Products)

Synonyms: 2610008M13Rik antibody, 40kDa antibody, AI326953 antibody, Recc2 antibody, RFC40 antibody, replication factor C subunit 2 antibody, replication factor C (activator 1) 2 antibody, LOC100231971 antibody, RFC2 antibody, Rfc2 antibody

Background:

Synonyms: A1 40 kDa subunit,A1,Activator 1 40 kDa subunit,Activator 1,Activator 1 subunit 2,MGC3665,OTTHUMP00000160645,OTTHUMP00000160646,Replication factor C (activator 1) 2 40  kDa,Replication factor C (activator 1) 2,Replication factor C 2,Replication factor C 40 kDa subunit,Replication factor C subunit 2,RF C 40 kDa subunit,RF-C 40 kDa subunit,RFC 2,RFC 40,RFC 40 kDa subunit,RFC2,RFC2,RFC40

Background: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.

Molecular Weight:

Observed_MW: 38kDa

Calculated_MW: 35kDa/39kDa

Gene ID: 5982

UniProt: P35250

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA