CASC5 antibody (AA 1-300)

Catalog No. ABIN6137952

Product Details anti-CASC5 Antibody

Target: CASC5 (Cancer Susceptibility Candidate 5 (CASC5))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MDGVSSEANE ENDNIERPVR RRHSSILKPP RSPLQDLRGG NERVQESNAL RNKKNSRRVS FADTIKVFQT ESHMKIVRKS EMEGCSAMVP SQLQLLPPGF KRFSCLSLPE TETGENLLLI QNKKLEDNYC EITGMNTLLS APIHTQMQQK EFSIIEHTRE RKHANDQTVI FSDENQMDLT SSHTVMITKG LLDNPISEKS TKIDTTSFLA NLKLHTEDSR MKKEVNFSVD QNTSSENKID FNDFIKRLKT GKCSAFPDVP DKENFEIPIY SKEPNSASST HQMHVSLKED ENNSNITRLF

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CASC5

Target: CASC5 (Cancer Susceptibility Candidate 5 (CASC5))

Alternative Name: CASC5 (CASC5 Products)

Synonyms: AF15Q14 antibody, CT29 antibody, D40 antibody, KNL1 antibody, PPP1R55 antibody, Spc7 antibody, hKNL-1 antibody, hSpc105 antibody, 2310043D08Rik antibody, 5730505K17Rik antibody, Rad51 antibody, kinetochore scaffold 1 antibody, Kinetochore null protein 1 antibody, KNL1 antibody, Knl1 antibody, knl-1 antibody

Background: The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.,AF15Q14,CASC5,CT29,D40,MCPH4,PPP1R55,Spc7,hKNL-1,hSpc105,KNL1,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centromere,Stem Cells,Germline Stem Cells,CASC5

Molecular Weight: 195 kDa/205 kDa/262 kDa/265 kDa

Gene ID: 57082

UniProt: Q8NG31

Pathways: Maintenance of Protein Location, Autophagy