CTLA4 antibody (AA 49-223)

Catalog No. ABIN6139198

The Rabbit Polyclonal anti-CTLA4 antibody has been validated for WB. It is suitable to detect CTLA4 in samples from Human.

Quick Overview for CTLA4 antibody (AA 49-223) (ABIN6139198)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CTLA4 Antibody

Binding Specificity: AA 49-223

Sequence: SSRGIASFVC EYASPGKATE VRVTVLRQAD SQVTEVCAAT YMMGNELTFL DDSICTGTSS GNQVNLTIQG LRAMDTGLYI CKVELMYPPP YYLGIGNGTQ IYVIDPEPCP DSDFLLWILA AVSSGLFFYS FLLTAVSLSK MLKKRSPLTT GVYVKMPPTE PECEKQFQPY FIPIN

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 49-223 of human CTLA4 (NP_005205.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CTLA4

Background: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.,CTLA4,ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,CTLA4

Molecular Weight: 6 kDa/8 kDa/19 kDa/24 kDa

Gene ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints