TRPM8 antibody (AA 980-1104)
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- Target See all TRPM8 Antibodies
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
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Binding Specificity
- AA 980-1104
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRPM8 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GYTVGTVQEN NDQVWKFQRY FLVQEYCSRL NIPFPFIVFA YFYMVVKKCF KCCCKEKNME SSVCCFKNED NETLAWEGVM KENYLVKINT KANDTSEEMR HRFRQLDTKL NDLKGLLKEI ANKIK
- Cross-Reactivity
- Human
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 980-1104 of human TRPM8 (NP_076985.4).
- Isotype
- IgG
- Top Product
- Discover our top product TRPM8 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Alternative Name
- TRPM8 (TRPM8 Products)
- Synonyms
- TRPM8 antibody, trpp8 antibody, ltrpc6 antibody, trpm8b antibody, LTRPC6 antibody, TRPP8 antibody, CMR1 antibody, LTrpC-6 antibody, Trp-p8 antibody, transient receptor potential cation channel subfamily M member 8 antibody, transient receptor potential cation channel subfamily M member 8b L homeolog antibody, transient receptor potential cation channel, subfamily M, member 8 antibody, TRPM8 antibody, trpm8b.L antibody, Trpm8 antibody
- Background
- Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.,TRPM8,LTRPC6,TRPP8,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,TRPM8
- Molecular Weight
- 5 kDa/18 kDa/79 kDa/127 kDa
- Gene ID
- 79054
- UniProt
- Q7Z2W7
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