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BCL6 antibody (AA 256-389)
BCL6
Reactivity: Human
WB, FACS, IF, IHC (p)
Host: Mouse
Monoclonal
BCL6-1526
unconjugated
Product Details anti-BCL6 Antibody
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Target
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BCL6
(B-Cell CLL/lymphoma 6 (BCL6))
Binding Specificity
All epitopes for BCL6 antibodies
AA 256-389
Reactivity
All reactivities for BCL6 antibodies
Human
Host
All hosts for BCL6 antibodies
Mouse
Clonality
All clonalities for BCL6 antibodies
Monoclonal
Conjugate
All conjugates for BCL6 antibodies
This BCL6 antibody is un-conjugated
Application
All applications for BCL6 antibodies
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
Protein G affinity chromatography
Immunogen
Amino acids 256-389 from the human protein were used as the immunogen for the Bcl6 antibody.
Clone
BCL6-1526
Isotype
IgG1 kappa
Top Product
Discover our top product BCL6 Primary Antibody
Alternatives
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Application Details
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Application Notes
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml Immunofluorescence: 1-2 μg/mL IHC (FFPE): 1-2 μg/mL for 30 min at RT Optimal dilution of the Bcl6 antibody should be determined by the researcher.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and Store at -20C. Avoid freez-thaw cycles.
Target Details for BCL6
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Target
BCL6
(B-Cell CLL/lymphoma 6 (BCL6))
Alternative Name
Bcl6 (BCL6 Products )
Synonyms
bcl5 antibody, laz3 antibody, bcl6a antibody, znf51 antibody, zbtb27 antibody, MGC132260 antibody, Bcl5 antibody, BCL5 antibody, BCL6A antibody, LAZ3 antibody, ZBTB27 antibody, ZNF51 antibody, B-cell CLL/lymphoma 6 L homeolog antibody, B-cell CLL/lymphoma 6 antibody, B cell leukemia/lymphoma 6 antibody, bcl6.L antibody, bcl6 antibody, BCL6 antibody, Bcl6 antibody
Background
Antibody to Bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show Bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Gene ID
604
UniProt
P41182
Pathways
Chromatin Binding , Regulation of Leukocyte Mediated Immunity , Production of Molecular Mediator of Immune Response , Protein targeting to Nucleus
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