SQSTM1 antibody (pSer403)
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- Target See all SQSTM1 Antibodies
- SQSTM1 (Sequestosome 1 (SQSTM1))
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Binding Specificity
- pSer403
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SQSTM1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- Phospho-SQSTM1/p62 (Ser403) Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser403.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human SQSTM1/p62 around the phosphorylation site of Ser403.
- Isotype
- IgG
- Top Product
- Discover our top product SQSTM1 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner." in: Human molecular genetics, Vol. 27, Issue 4, pp. 667-678, (2018) (PubMed).
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Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner." in: Human molecular genetics, Vol. 27, Issue 4, pp. 667-678, (2018) (PubMed).
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- Target
- SQSTM1 (Sequestosome 1 (SQSTM1))
- Alternative Name
- SQSTM1 (SQSTM1 Products)
- Synonyms
- SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody
- Background
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Description: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102).
Gene: SQSTM1
- Molecular Weight
- 62kDa
- Gene ID
- 8878
- UniProt
- Q13501
- Pathways
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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