CC2D1A antibody (Internal Region)

Catalog No. ABIN6257986

Product Details anti-CC2D1A Antibody

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CC2D1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: CC2D1A Antibody detects endogenous levels of total CC2D1A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CC2D1A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CC2D1A

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Alternative Name: CC2D1A (CC2D1A Products)

Synonyms: mrt3 antibody, freud-1 antibody, FREUD-1 antibody, Freud-1/Aki1 antibody, MRT3 antibody, BC016188 antibody, Freud-1 antibody, Tape antibody, RGD1306108 antibody, coiled-coil and C2 domain containing 1A antibody, CC2D1A antibody, cc2d1a antibody, Cc2d1a antibody

Background:

Description: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

Gene: CC2D1A

Molecular Weight: 130 kDa

Gene ID: 54862

UniProt: Q6P1N0