CYP26B1 antibody (Internal Region)

Catalog No. ABIN6261169

Product Details anti-CYP26B1 Antibody

Target: CYP26B1 (Cytochrome P450, Family 26, Subfamily B, Polypeptide 1 (CYP26B1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP26B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CYP26B1 Antibody detects endogenous levels of total CYP26B1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CYP26B1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CYP26B1

Target: CYP26B1 (Cytochrome P450, Family 26, Subfamily B, Polypeptide 1 (CYP26B1))

Alternative Name: CYP26B1 (CYP26B1 Products)

Synonyms: cyp26b1 antibody, cyp26a2 antibody, p450rai-2 antibody, CYP26A2 antibody, P450RAI-2 antibody, P450RAI2 antibody, RHFCA antibody, CP26 antibody, fc21d03 antibody, wu:fc21d03 antibody, wu:fc26h10 antibody, zgc:76999 antibody, cytochrome P450 26B1 antibody, cytochrome P450 family 26 subfamily B member 1 L homeolog antibody, cytochrome P450 family 26 subfamily B member 1 antibody, cytochrome P450, family 26, subfamily B, polypeptide 1 antibody, cytochrome P450, family 26, subfamily b, polypeptide 1 antibody, CpipJ_CPIJ002537 antibody, cyp26b1.L antibody, CYP26B1 antibody, cyp26b1 antibody, Cyp26b1 antibody

Background:

Description: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.

Gene: CYP26B1

Molecular Weight: 58-60 kDa

Gene ID: 56603

UniProt: Q9NR63

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Monocarboxylic Acid Catabolic Process