ERCC6 antibody (Internal Region)
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- Target See all ERCC6 Antibodies
- ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ERCC6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- ERCC6 Antibody detects endogenous levels of total ERCC6.
- Predicted Reactivity
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ERCC6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ERCC6 Primary Antibody
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- Application Notes
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))
- Alternative Name
- ERCC6 (ERCC6 Products)
- Synonyms
- ARMD5 antibody, CKN2 antibody, COFS antibody, COFS1 antibody, CSB antibody, RAD26 antibody, UVSS1 antibody, 4732403I04 antibody, C130058G22Rik antibody, ercc6 antibody, Ercc6 antibody, ERCC excision repair 6, chromatin remodeling factor antibody, excision repair cross-complementing rodent repair deficiency, complementation group 6 antibody, excision repair cross-complementation group 6 antibody, DNA excision repair protein ERCC-6 antibody, ERCC6 antibody, Ercc6 antibody, ercc6 antibody, LOC100719487 antibody
- Background
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Description: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
Gene: ERCC6
- Molecular Weight
- 168 kDa
- Gene ID
- 2074
- UniProt
- Q03468
- Pathways
- DNA Damage Repair, Chromatin Binding
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