AIMP2 antibody (Internal Region)

Catalog No. ABIN6262712

Product Details anti-AIMP2 Antibody

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: AIMP2/p38 Antibody detects endogenous levels of total AIMP2/p38.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human AIMP2/p38, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for AIMP2

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Alternative Name: AIMP2 (AIMP2 Products)

Synonyms: jtv1 antibody, MGC53242 antibody, pro0992 antibody, JTV1 antibody, JTV-1 antibody, P38 antibody, AA407136 antibody, AA407225 antibody, Aimp2(p38) antibody, Jtv1 antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 L homeolog antibody, aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 antibody, aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody, aimp2.L antibody, aimp2 antibody, AIMP2 antibody, Aimp2 antibody

Background:

Description: Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Gene: AIMP2

Molecular Weight: 36 kDa

Gene ID: 7965

UniProt: Q13155