PPP1CB antibody
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- Target See all PPP1CB Antibodies
- PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PPP1CB antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- PPP1CB Antibody detects endogenous levels of total PPP1CB
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PPP1CB
- Isotype
- IgG
- Top Product
- Discover our top product PPP1CB Primary Antibody
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- PPP1CB (Protein Phosphatase 1, Catalytic Subunit, beta Isoform (PPP1CB))
- Alternative Name
- PPP1CB (PPP1CB Products)
- Synonyms
- PP-1B antibody, PP1B antibody, PP1beta antibody, PPP1CD antibody, 1200010B19 antibody, ik:tdsubc_2f2 antibody, si:zc214p16.4 antibody, wu:fa09h01 antibody, wu:fa11e06 antibody, xx:tdsubc_2f2 antibody, PP2CB antibody, Ppp1cb antibody, protein phosphatase 1 catalytic subunit beta antibody, protein phosphatase 1, catalytic subunit, beta isoform antibody, protein phosphatase 1, catalytic subunit, beta isozyme L homeolog antibody, protein phosphatase 1, catalytic subunit, beta isozyme antibody, serine/threonine-protein phosphatase PP1-beta catalytic subunit antibody, protein phosphatase 1B, magnesium dependent, beta isoform antibody, PPP1CB antibody, Ppp1cb antibody, ppp1cb.L antibody, ppp1cb antibody, LOC100224238 antibody, Ppm1b antibody
- Background
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Description: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Gene: PPP1CB
- Molecular Weight
- 37kDa
- Gene ID
- 5500
- UniProt
- P62140
- Pathways
- M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism
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