TRF1 antibody (Internal Region)
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- Target See all TRF1 (TERF1) Antibodies
- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRF1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- TRF1 Antibody detects endogenous levels of total TRF1.
- Predicted Reactivity
- Horse,Sheep
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TRF1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TERF1 Primary Antibody
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- Application Notes
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
- Alternative Name
- TERF1 (TERF1 Products)
- Synonyms
- PIN2 antibody, TRBF1 antibody, TRF antibody, TRF1 antibody, hTRF1-AS antibody, t-TRF1 antibody, wu:fb74c04 antibody, TERF1 antibody, DKFZp459A0713 antibody, Pin2 antibody, Trbf1 antibody, Trf1 antibody, terf1 antibody, trf1 antibody, telomeric repeat binding factor 1 antibody, telomeric repeat binding factor (NIMA-interacting) 1 antibody, telomeric repeat binding factor (NIMA-interacting) 1 L homeolog antibody, TERF1 antibody, Terf1 antibody, terf1 antibody, Trf1 antibody, terf1.L antibody
- Background
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Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Gene: TERF1
- Molecular Weight
- 50kDa
- Gene ID
- 7013
- UniProt
- P54274
- Pathways
- Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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