ERBB3 antibody (pTyr1197)

Catalog No. ABIN6280961

Product Details anti-ERBB3 Antibody

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Binding Specificity: AA 1140-1220, pTyr1197

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: ErbB-3 is a protein encoded by the ERBB3 gene which is approximately 148 kDa. ErbB-3 isoform 1 is localised to the cell membrane and isoform 2 is secreted. It is involved in RET signalling, GPCR pathway, GAB1 signalosome, signalling by ERBB2 and ERK signalling. The protein fall under the epidermal growth factor receptor family of receptor tyrosine kinases. It plays an essential role as a cell surface receptor for neuregulins. It binds to neuregulin-1 and is also activated by it. ErbB-3 is expressed in the brain and epithelial tissues. Mutations in the ERBB3 gene result in lethal congenital contracture syndrome. STJ90642 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous ErbB-3 protein which only binds about Y1197 when Y1197 is phosphorylated.

Specificity: Phospho-ErbB-3 (Y1197) Polyclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1197.

Characteristics: Rabbit polyclonal to Phospho-ErbB-3 (Y1197).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human ErbB-3 around the phosphorylation site of Y1197.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
ELISA 1:40000

Comment:

Epithelial tissues and brain.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: ErbB-3 (ERBB3 Products)

Synonyms: ErbB-3 antibody, HER3 antibody, LCCS2 antibody, MDA-BF-1 antibody, c-erbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody, ERBB3 antibody, C76256 antibody, Erbb-3 antibody, Erbb3r antibody, Her3 antibody, nuc-ErbB3 antibody, erb-b2 receptor tyrosine kinase 3 antibody, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, ERBB3 antibody, Erbb3 antibody

Molecular Weight: 160-170 kDa

Gene ID: 2065

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway