Cyclin D1 antibody (AA 220-300)
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- Target See all Cyclin D1 (CCND1) Antibodies
- Cyclin D1 (CCND1)
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Binding Specificity
- AA 220-300
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cyclin D1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Cyclin D1 is a protein encoded by the CCND1 gene which is approximately 33,7 kDa. Cyclin D1 is localised to the nucleus and cytoplasm. It is involved in CDK-mediated phosphorylation and removal of Cdc6, cyclins and cell cycle regulation. This protein falls under the highly conserved cyclin family. It is a regulatory component of the cyclin D1-CDK4 complex that phosphorylates and inhibits members of the retinoblastoma protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D1 is expressed in the nervous system, liver, skin, intestine and lung. Mutations in the CCND1 gene may result in multiple myeloma. STJ92538 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin D1 protein.
- Specificity
- Cyclin D1 Polyclonal Antibody detects endogenous levels of Cyclin D1 protein.
- Characteristics
- Rabbit polyclonal to Cyclin D1.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286.
- Isotype
- IgG
- Top Product
- Discover our top product CCND1 Primary Antibody
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- Application Notes
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- Cyclin D1 (CCND1)
- Alternative Name
- Cyclin D1 (CCND1 Products)
- Synonyms
- BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody
- Molecular Weight
- 36 kDa
- Gene ID
- 595
- UniProt
- P24385
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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