BCL6 antibody (Internal Region)

Catalog No. ABIN6282755

Product Details anti-BCL6 Antibody

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Binding Specificity: AA 271-320, Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Bcl-6 is a protein encoded by the BCL6 gene which is approximately 78,8 kDa. Bcl-6 is localised to the nucleus. It is involved in cytokine signalling in immune system, gene expression and FoxO signalling pathway. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. It is mainly required for germinal centre formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. It forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Bcl-6 is expressed in germinal centre T- and B-cells and in primary immature dendritic cells. Mutations in the BCL6 gene may result in b-cell lymphomas. STJ96676 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bcl-6 protein.

Specificity: Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

Characteristics: Rabbit polyclonal to Bcl-6.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Bcl-6.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000

Comment:

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: Bcl-6 (BCL6 Products)

Synonyms: bcl5 antibody, laz3 antibody, bcl6a antibody, znf51 antibody, zbtb27 antibody, MGC132260 antibody, Bcl5 antibody, BCL5 antibody, BCL6A antibody, LAZ3 antibody, ZBTB27 antibody, ZNF51 antibody, B-cell CLL/lymphoma 6 L homeolog antibody, B-cell CLL/lymphoma 6 antibody, B cell leukemia/lymphoma 6 antibody, bcl6.L antibody, bcl6 antibody, BCL6 antibody, Bcl6 antibody

Molecular Weight: 78 kDa

Gene ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus