Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purpose
E2F-1 is a protein encoded by the E2F1 gene which is approximately 46,9 kDa. E2F-1 is localised to the nucleus. It is involved in glioma, cyclins and cell cycle regulation and activation of BH3-only proteins. It plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. E2F-1 is expressed in the skin, pancreas and the nervous system. Mutations in the E2F1 gene may result in retinoblastoma pharyngoconjunctival fever. STJ92807 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous levels of E2F-1 (Acetyl Lys120).
Specificity
E2F-1 Polyclonal Antibody detects endogenous levels of E2F-1 protein.
Characteristics
Rabbit polyclonal to E2F-1.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Synthesized peptide derived from human E2F-1 around the non-phosphorylation site of T433.