ABCC5 antibody
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- Target See all ABCC5 Antibodies
- ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ABCC5 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide of human ABCC5
- Isotype
- IgG
- Top Product
- Discover our top product ABCC5 Primary Antibody
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- Application Notes
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WB 1:500 - 1:2000
IHC 1:50 - 1:200 - Comment
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All isoforms are equally expressed in retina
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))
- Alternative Name
- ABCC5 (ABCC5 Products)
- Synonyms
- ABC33 antibody, EST277145 antibody, MOAT-C antibody, MOATC antibody, MRP5 antibody, SMRP antibody, pABC11 antibody, 2900011L11Rik antibody, AI132311 antibody, Abcc5a antibody, Abcc5b antibody, Mrp5 antibody, abc33 antibody, abcc5 antibody, moat-c antibody, moatc antibody, mrp5 antibody, pabc11 antibody, smrp antibody, ATP binding cassette subfamily C member 5 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 antibody, ATP binding cassette subfamily C member 5 L homeolog antibody, ABCC5 antibody, Abcc5 antibody, abcc5.L antibody
- Background
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
- Molecular Weight
- 160.66 kDa
- Gene ID
- 10057
- UniProt
- O15440
- Pathways
- Glycosaminoglycan Metabolic Process
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