pi8 antibody, cap2 antibody, CAP-2 antibody, CAP2 antibody, NK10 antibody, Spi8 antibody, ovalbumin antibody, PI8 antibody, serpin family B member 8 antibody, serpin B8 antibody, serpin peptidase inhibitor, clade B (ovalbumin), member 8 antibody, serine (or cysteine) peptidase inhibitor, clade B, member 8 antibody, Serpinb8 antibody, SERPINB8 antibody, LOC607205 antibody, serpinb8 antibody, LOC100424017 antibody
Background
The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis.