IKAP/p150 antibody

Catalog No. ABIN6566783

Product Details anti-IKAP/p150 Antibody

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IKAP/p150 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human IKBKAP

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:4000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IKAP/p150

Target: IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

Alternative Name: IKBKAP (ELP1 Products)

Synonyms: DYS antibody, ELP1 antibody, FD antibody, IKAP antibody, IKI3 antibody, TOT1 antibody, IKBKAP antibody, DKFZp469N1415 antibody, 3110040G09Rik antibody, 6030413P05 antibody, C78473 antibody, Elp1 antibody, Ikbkap antibody, elongator complex protein 1 antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein antibody, ielongator complex protein 1 S homeolog antibody, inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein antibody, ELP1 antibody, Elp1 antibody, IKBKAP antibody, elp1.S antibody, elp1 antibody, Ikbkap antibody

Background:

Synonyms: DKFZp781H1425,DYS,Dysautonomia (Riley Day syndrome hereditary sensory autonomic neuropathy type III),Elongator complex protein 1,ELP 1,ELP1,ELP1,FD,FLJ12497,IKAP,IkappaB kinase complex associated protein,IkappaB kinase complex-associated protein,ikbkap,IKI 3,IKI3,IKK complex associated protein,IKK complex-associated protein,Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein,OTTHUMP00000063889,p150,TOT 1,TOT1

Background: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight:

Observed_MW: 150kDa

Calculated_MW: 150kDa

Gene ID: 8518

UniProt: O95163