PML antibody
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- Target See all PML Antibodies
- PML (Promyelocytic Leukemia (PML))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PML antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human PML
- Isotype
- IgG
- Top Product
- Discover our top product PML Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PML (Promyelocytic Leukemia (PML))
- Alternative Name
- PML (PML Products)
- Synonyms
- MYL antibody, PP8675 antibody, RNF71 antibody, TRIM19 antibody, 1200009E24Rik antibody, AI661194 antibody, Trim19 antibody, RGD1562602 antibody, PML antibody, promyelocytic leukemia antibody, PML antibody, Pml antibody
- Background
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Synonyms: Acure promyelocytic leukemia,inducer of,MYL,Pml,PML,PP8675,Probable transcription factor PML,Promyelocytic leukemia,Promyelocytic leukemia inducer of,Promyelocytic leukemia protein,Protein PML,RING finger protein 71,RNF 71,RNF71,TRIM 19,Tripartite motif protein TRIM19,Tripartite motif-containing protein 19
Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
- Molecular Weight
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Observed_MW: 98kDa
Calculated_MW: 47-48kDa/62-97kDa
- Gene ID
- 5371
- UniProt
- P29590
- Pathways
- p53 Signaling, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
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