UIMC1 antibody

Catalog No. ABIN6568375

Product Details anti-UIMC1 Antibody

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UIMC1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human UIMC1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UIMC1

Target: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Alternative Name: UIMC1 (UIMC1 Products)

Synonyms: UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody

Background:

Synonyms: BRCA1-A complex subunit RAP80,Nuclear zinc finger protein RAP80,OTTHUMP00000161441,OTTHUMP00000223372,OTTHUMP00000223374,RAP80,Receptor associated protein 80,Receptor-associated protein 80,Retinoid X receptor interacting protein 110,Retinoid x receptor interacting protein,Retinoid X receptor-interacting protein 110,RIP110,Rxrip110,Ubiquitin interaction motif containing 1,Ubiquitin interaction motif containing protein 1,Ubiquitin interaction motif-containing protein 1,UIMC1,UIMC1,X2HRIP110

Background: This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 90kDa

Calculated_MW: 17kDa/38kDa/61kDa/70kDa/79kDa

Gene ID: 51720

UniProt: Q96RL1

Pathways: DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus