RNASEH2A antibody

Catalog No. ABIN5964810

Product Details anti-RNASEH2A Antibody

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human RNASEH2A (NP_006388.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RNASEH2A

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Alternative Name: RNASEH2A (RNASEH2A Products)

Synonyms: 2400006P09Rik antibody, RNASEHI antibody, RNHIA antibody, RNHL antibody, zgc:56307 antibody, AGS4 antibody, JUNB antibody, ribonuclease H2 subunit A antibody, ribonuclease H2, large subunit antibody, ribonuclease H2, subunit A antibody, ribonuclease H2 subunit A L homeolog antibody, rnaseh2a antibody, RNASEH2A antibody, Rnaseh2a antibody, rnaseh2a.L antibody

Background: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Molecular Weight:

Observed_MW: 33kDa

Calculated_MW: 33kDa

Gene ID: 10535

UniProt: O75792