IL12RB1 antibody
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- Target See all IL12RB1 Antibodies
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IL12RB1 antibody is un-conjugated
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human IL12RB1 (NP_714912.1).
- Isotype
- IgG
- Top Product
- Discover our top product IL12RB1 Primary Antibody
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- Application Notes
- IF 1:10-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Alternative Name
- IL12RB1 (IL12RB1 Products)
- Synonyms
- Il12rb antibody, IL12RB1 antibody, IL-12R antibody, CD212 antibody, IL-12R-BETA1 antibody, IL12RB antibody, IL-12R[b] antibody, interleukin 12 receptor subunit beta 1 antibody, interleukin 12 receptor, beta 1 antibody, Il12rb1 antibody, IL12RB1 antibody
- Background
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
- Molecular Weight
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Observed_MW: 73kDa
Calculated_MW: 42kDa/72kDa/73kDa
- Gene ID
- 3594
- UniProt
- P42701
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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