KCNQ4 antibody (N-Term)

Catalog No. ABIN6656738

Product Details anti-KCNQ4 Antibody

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Binding Specificity: N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNQ4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: Anti-KCNQ4 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with KCNQ4 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with KCNQ4 from other sources has not been determined. Channels and Transporters research.

Immunogen:

Immunogen: KCNQ4 Antibody was produced in mice by repeated immunizations raised against a fusion protein n-terminal region of human KCNQ4.

Immunogen Type: Peptide

Clone: S43-6

Isotype: IgG1

Application Details

Application Notes:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-KCNQ4 Antibody is suitable for use in WB, IP, and IF microscopy. Expect a band approximately ~77 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1-10 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: RT,4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Target Details for KCNQ4

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Alternative Name: KCNQ4 (KCNQ4 Products)

Synonyms: KCNQ4 antibody, k(v)7.4 antibody, kv7.4 antibody, DFNA2 antibody, DFNA2A antibody, KV7.4 antibody, potassium voltage-gated channel subfamily Q member 4 antibody, potassium channel, voltage gated KQT-like subfamily Q, member 4 antibody, potassium voltage-gated channel, subfamily Q, member 4 antibody, KCNQ4 antibody, kcnq4 antibody, Kcnq4 antibody

Background:

Synonyms: DFNA2, KQT like 4, Kv7.4, voltage gated potassium channel subunit Kv7.4, IKs producing slow voltage-gated potassium channel subunit alpha, KvLQT4, KQT-like 4, Potassium voltage-gated channel subfamily KQT member 4

Background: Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug.

Gene Name: KCNQ4

Gene ID: 9132

NCBI Accession: NP_004691

UniProt: P56696

Pathways: Sensory Perception of Sound