GABRB1 antibody (Cytoplasmic Loop)

Catalog No. ABIN6658240

Product Details anti-GABRB1 Antibody

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Binding Specificity: Cytoplasmic Loop

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Purification: Anti-GABA(A) Receptor beta 1 Antibody is directed against rat GABA(A) Receptor beta 1. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, non-human primate, Xenopus, and zebra fish.

Immunogen:

Immunogen: Anti-GABA(A) Receptor beta 1 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the beta 1 subunit.

Immunogen Type: Recombinant Protein

Isotype: IgG

Application Details

Application Notes:

Application Note: Anti-GABA(A) Receptor beta 1 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the beta 1 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Target Details for GABRB1

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Alternative Name: GABA(A) Receptor beta 1 (GABRB1 Products)

Synonyms: AW061132 antibody, B230208N19Rik antibody, Gabrb-1 antibody, GARB1 antibody, si:dkey-20i10.4 antibody, gamma-aminobutyric acid type A receptor beta1 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 antibody, gamma-aminobutyric acid type A receptor beta 1 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, beta 1 antibody, GABRB1 antibody, Gabrb1 antibody, gabrb1 antibody

Background:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit ß-1,

Background: Anti-GABA(A) Receptor beta 1 Antibody detects GABA(A) Receptor beta 1. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 1 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB1

Gene ID: 25450

UniProt: P15431