MMP2 antibody (Matrix Metalloproteinase 2) (AA 20-70)

Details for Product anti-MMP2 Antibody No. ABIN668286, Supplier: Log in to see
Antigen
  • 2-MMP
  • CG1794
  • DM2-MMP
  • Dm2-MMP
  • Dmel\\CG1794
  • MMP2
  • anon-WO0118547.84
  • dm-2MMP
  • dmmp2
  • l(2)02353
  • mmp2
  • wu:fa99h12
  • wu:fk89d01
  • fgmmp-2
  • Mmp-2
  • LOC100135793
  • Clg4a
  • GelA
  • MMP-2
  • CLG4
  • CLG4A
  • MMP-II
  • MONA
  • TBE-1
  • matrix metallopeptidase 2
  • Matrix metalloproteinase 2
  • matrix metalloproteinase 2
  • matrix metalloproteinase-2
  • MMP2
  • Mmp2
  • mmp2
  • LOC657982
  • LOC100135793
Alternatives
anti-Rat (Rattus) MMP2 antibody for Immunoprecipitation
Epitope
AA 20-70
21
20
18
15
15
15
12
10
10
10
8
8
7
7
6
5
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
397
183
173
29
16
15
13
11
7
6
6
5
4
2
2
2
2
2
1
1
1
Host
Rabbit
249
177
2
2
1
1
Clonality
Polyclonal
Conjugate
This MMP2 antibody is un-conjugated
20
17
15
8
8
6
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
326
151
112
107
90
73
64
60
54
38
19
6
5
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen MAT conjugated synthetic peptide derived from human MMP2
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others MMP2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name MMP2 (MMP2 Antibody Abstract)
Background

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Subcellular location: Secreted

Synonyms: CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP2

Gene ID 4313
UniProt P08253
Pathways Activation of Innate immune Response
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-MMP-2 Polyclo...
Immunohistochemistry (IHC) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (Image 2)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded Mouse lung, Antigen retrieval by boiling in...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Formalin-fixed and paraffin embedded rat carotid artery Anti-MMP-2 Polyclonal Antibod...
 image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) HT1080 lysates probed with MMP-2 Polyclonal Antibody, Unconjugated at 1:300 dilution...
 image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) HeLa cells probed with MMP2 Polyclonal Antibody, unconjugated at 1:100 dilution for ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Matrix Metalloproteinase 2 (MMP2) (AA 20-70) antibody (ABIN668286) Paraformaldehyde-fixed, paraffin embedded Rat Brain Antigen retrieval by boiling in s...
Product cited in: Gao, Li, Liu, Wang, Zhang, Li, Bu: "Effect of Telmisartan on Preventing Learning and Memory Deficits Via Peroxisome Proliferator-Activated Receptor-γ in Vascular Dementia Spontaneously Hypertensive Rats." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 27, Issue 2, pp. 277-285, 2018 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: brain

Wang, Chen, Ke, Li: "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." in: Peptides, Vol. 90, pp. 17-26, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rabbit). Further details: Sample: abdominal aorta

Varghese, Joseph, S R, B S, Sreelekha: "The inhibitory effect of anti- tumor polysaccharide from Punica granatum on metastasis." in: International journal of biological macromolecules, Vol. 103, pp. 1000-1010, 2017 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Vendrov, Stevenson, Alahari, Pan, Wickline, Madamanchi, Runge: "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." in: Journal of the American Heart Association, Vol. 6, Issue 11, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Frozen Sections) (IHC (fro)) (Sample species: Mouse (Murine)). Further details: Sample: heart

Ni, Ding, Zhou, Qiu, Tang: "Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats." in: European journal of pharmacology, Vol. 764, pp. 448-456, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Kidney

Madka, Mohammed, Li, Zhang, Kumar, Lightfoot, Wu, Steele, Kopelovich, Rao: "TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma." in: American journal of cancer research, Vol. 5, Issue 10, pp. 3030-41, 2015 (PubMed). Method employed by authors: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)). Further details: Sample: bladder tumor

Zhu, Chen, Chen, Chen, Song, Sun, Zhao: "Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients." in: PLoS ONE, Vol. 9, Issue 7, pp. e103882, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).

Zhang, Qi, Cao, Zu, Chen, Li, Qi: "5-Aza-2'-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line." in: Cancer biotherapy & radiopharmaceuticals, 2013 (PubMed).

Qin, Fan, Zhao, Cui, Wei, Kohama, Gordon, Li, Gao: "Recombinant human CXCL8(3-72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin-8 receptor." in: IUBMB life, Vol. 65, Issue 1, pp. 67-75, 2013 (PubMed). (Sample species: Mouse (Murine)). Further details: Sample: heart

Fang, Wu, Huang: "Raloxifene upregulated mesangial cell MMP-2 activity via ER-? through transcriptional regulation." in: Cell biochemistry and biophysics, Vol. 67, Issue 2, pp. 607-13, 2013 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Wu, Ning, Zeng, Fan, Zhou, Zhang, Zhang, Chen, Gao, Wang, Guo, Li, Wang, He: "Silibinin inhibits ?-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial-mesenchymal transition and stemness." in: Cellular signalling, Vol. 25, Issue 12, pp. 2625-33, 2013 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: "PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription." in: Cellular signalling, Vol. 24, Issue 12, pp. 2273-82, 2012 (PubMed). (Sample species: Mouse (Murine)). Further details: Sample: xenograft tissues

Wu, Zeng, Zhou, Fan, Chen, Wang, Zhang, Wang, He: "Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development." in: Urologic oncology, 2012 (PubMed).

Wu, Zeng, Li, Fan, Zhang, Xue, Zhu, Yang, Wang, He: "Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors." in: Oncology reports, Vol. 23, Issue 6, pp. 1545-52, 2010 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Human).

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