CDK5 antibody (Cyclin-Dependent Kinase 5) (AA 1-45)

Details for Product anti-CDK5 Antibody No. ABIN670101
Antigen
  • PSSALRE
  • AW048668
  • Crk6
  • CDK5
  • CG8203
  • DmCdk5
  • Dmel\\CG8203
  • cdk5
  • zgc:101604
  • cyclin dependent kinase 5
  • cyclin-dependent kinase 5
  • Cyclin-dependent kinase 5
  • cyclin-dependent kinase 5 L homeolog
  • Cyclin-dependent-like kinase 5
  • CDK5
  • Cdk5
  • cdk5
  • cdk5.L
  • cdk-5
Epitope
AA 1-45
41
17
17
14
14
9
9
6
5
4
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
268
174
169
19
19
17
16
15
13
13
10
9
5
5
3
3
3
2
1
1
1
Host
Rabbit
205
72
Clonality
Polyclonal
Conjugate
This CDK5 antibody is un-conjugated
12
7
6
6
6
6
6
6
5
2
2
2
2
2
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
214
102
59
42
35
31
26
18
18
12
5
3
3
Options
Immunogen KLH conjugated synthetic peptide derived from human CDK5
Isotype IgG
Specificity This antibody will detect both isoform variants of this protein. Due to similar amino acid composition of this protein to CDK3 in human, there is a chance that this antibody will react with CDK3 in human, based on an 83 % sequence similarity.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others CDK5 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CDK5 (CDK5 Antibody Abstract)
Background

CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

Subcellular location: Cytoplasm

Synonyms: PSSALRE, Cyclin-dependent-like kinase 5, Cell division protein kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5, CDKN5

Gene ID 1020
UniProt Q00535
Pathways Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-45) antibody (ABIN670101) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-CDK5 Polyclonal Anti...
Image no. 2 for anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-45) antibody (ABIN670101) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-CDK5 Polyclon...
Image no. 3 for anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-45) antibody (ABIN670101) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-CDK5 Polyclon...
Product cited in: Cao, Jia, Wei, Liu, Liu, Li: "Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 6840432, 2016 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: brain

Yin, Qi, Ren, Wang, Jiang, Feng, Cui: "Roscovitine treatment caused impairment of fertilizing ability in mice." in: Toxicology letters, Vol. 237, Issue 3, pp. 200-9, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: Testis

Li, Wang, Guo, Huang, Zhao, Zhu, Ma, Liang, Zhang, Huang, Wan: "Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism." in: Experimental and therapeutic medicine, Vol. 10, Issue 5, pp. 1643-1652, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Brain

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