BAP1 antibody (AA 191-326)
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- Target See all BAP1 Antibodies
- BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))
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Binding Specificity
- AA 191-326
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BAP1 antibody is un-conjugated
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Application
- ELISA, Coating (Coat)
- Specificity
- The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)
- Clone
- BAP1-2431
- Isotype
- IgG2c kappa
- Top Product
- Discover our top product BAP1 Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Jurkat or PC-3 or HepG2 cells. Testis, Placenta, Ovarian or Breast Carcinoma.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))
- Alternative Name
- BAP1 (BAP1 Products)
- Synonyms
- HUCEP-13 antibody, UCHL2 antibody, BAIAP3 antibody, 2300006C11Rik antibody, AA989761 antibody, AW553466 antibody, mKIAA0272 antibody, uch-x4 antibody, hucep-13 antibody, hucep-6 antibody, uchl2 antibody, si:dkey-42i9.9 antibody, BRCA1 associated protein 1 antibody, Brca1 associated protein 1 antibody, BRCA1 associated protein 1 L homeolog antibody, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antibody, BAP1 antibody, Bap1 antibody, bap1.L antibody, bap1 antibody
- Background
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BAP1, BRCA1 associated protein 1, Cerebral protein 13, Cerebral protein 6, HUCEP 13, Hucep 6, HUCEP13, Hucep6, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP1, UCHL2,BAP1 (BRCA1 Associated Protein 1)
Cellular localisation: Nuclear and Cytoplasmic - Molecular Weight
- 91kDa
- Gene ID
- 8314, 106674
- UniProt
- Q92560
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