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BRCA1 antibody (AA 445-620)

BRCA1 Reactivity: Human ELISA, Coat Host: Mouse Monoclonal BRCA1-1472 unconjugated
Catalog No. ABIN6936513
  • Target See all BRCA1 Antibodies
    BRCA1 (Breast Cancer 1 (BRCA1))
    Binding Specificity
    • 21
    • 18
    • 15
    • 15
    • 14
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 445-620
    Reactivity
    • 192
    • 36
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 162
    • 36
    • 2
    Mouse
    Clonality
    • 166
    • 34
    Monoclonal
    Conjugate
    • 93
    • 18
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This BRCA1 antibody is un-conjugated
    Application
    • 127
    • 66
    • 42
    • 42
    • 41
    • 37
    • 29
    • 24
    • 22
    • 12
    • 12
    • 9
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Coating (Coat)
    Specificity
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment (around aa 445-620) of human BRCA1 protein (exact sequence is proprietary)
    Clone
    BRCA1-1472
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product BRCA1 Primary Antibody
  • Application Notes

    Known_Application: ELISA (For coating use Ab at 2-4 μg/mL, order Ab without BSA), Optimal dilution for a specific application should be determined.

    Positive_Control: A431 or HeLa cells. Breast, Ovarian or Renal Cell Carcinoma.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    BRCA1 (Breast Cancer 1 (BRCA1))
    Alternative Name
    BRCA1 (BRCA1 Products)
    Synonyms
    BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody
    Background
    BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53,BRCA1 (Breast Marker)
    Cellular localisation: Cytoplasmic and Nuclear
    Molecular Weight
    220kDa
    Gene ID
    672, 194143
    UniProt
    P38398
    Pathways
    Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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