BCMA antibody (AA 78-184)

Catalog No. ABIN6936646

Product Details anti-BCMA Antibody

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Binding Specificity: AA 78-184

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCMA antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Clone: BCMA-2366

Isotype: IgG2c kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: NAMALWA cells. Tonsil or gastric carcinoma (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for BCMA

Target: BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))

Alternative Name: CD269 (TNFRSF17 Products)

Synonyms: TNFRSF17 antibody, BCM antibody, BCMA antibody, CD269 antibody, TNFRSF13A antibody, Tnfrsf13 antibody, Tnfrsf13a antibody, TNF receptor superfamily member 17 antibody, tumor necrosis factor receptor superfamily, member 17 antibody, Tnfrsf17 antibody, TNFRSF17 antibody

Background: B-cell maturation protein, BCMA, CD269, TNR17, Tumor necrosis factor receptor superfamily member 17 (TNFRSF17),CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein)
Cellular localisation: Cell Surface

Molecular Weight: 20kDa

Gene ID: 608, 2556

UniProt: Q02223