CD46 antibody
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- Target See all CD46 Antibodies
- CD46
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Reactivity
- Human, Baboon
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD46 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Specificity
- Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
- No Cross-Reactivity
- Horse (Equine)
- Immunogen
- Stimulated human leukocytes
- Clone
- 169-1-E4-3
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CD46 Primary Antibody
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- Application Notes
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Positive Control: K562, U937, HL60, HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil.
Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- CD46
- Alternative Name
- CD46 (CD46 Products)
- Synonyms
- AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
- Molecular Weight
- 52-58kDa
- Gene ID
- 4179
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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