DNMT3A antibody
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- Target See all DNMT3A Antibodies
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This DNMT3A antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant protein human Dnmt3a between 600-700 amino acids
- Clone
- 8A1
- Isotype
- IgG
- Top Product
- Discover our top product DNMT3A Primary Antibody
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- Application Notes
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WB 1:300-5000
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
- Alternative Name
- Dnmt3a (DNMT3A Products)
- Synonyms
- DNMT3A antibody, DNMT3A2 antibody, M.HsaIIIA antibody, MmuIIIA antibody, dnmt3a1 antibody, dnmt6 antibody, DNA methyltransferase 3 alpha antibody, DNA methyltransferase 3A antibody, DNA (cytosine-5-)-methyltransferase 3 alpha b antibody, DNMT3A antibody, Dnmt3a antibody, dnmt3a antibody, dnmt3ab antibody
- Background
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Synonyms: DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA, Dnmt3a, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A
Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
- Gene ID
- 1788
- UniProt
- Q9Y6K1
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