DNMT3A antibody
-
- Target See all DNMT3A Antibodies
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This DNMT3A antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)
- Cross-Reactivity
- Human
- Purification
- Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
- Immunogen
- Polyclonal antibody raised in rabbit against human DNMT3A, (DNA methyltransferase 3A), using a KLH-conjugated synthetic peptide corresponding to amino acids 44-58
- Top Product
- Discover our top product DNMT3A Primary Antibody
-
-
- Application Notes
-
WB 1:300-5000
ELISA 1:500-1000
IP(1-2 μg)
ChIP-seq() - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.75 μg/μL
- Buffer
- PBS with 0.05 % sodium azide and 0.05 % Proclin300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
-
- Target
- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
- Alternative Name
- DNMT3A (DNMT3A Products)
- Synonyms
- DNMT3A antibody, DNMT3A2 antibody, M.HsaIIIA antibody, MmuIIIA antibody, dnmt3a1 antibody, dnmt6 antibody, DNA methyltransferase 3 alpha antibody, DNA methyltransferase 3A antibody, DNA (cytosine-5-)-methyltransferase 3 alpha b antibody, DNMT3A antibody, Dnmt3a antibody, dnmt3a antibody, dnmt3ab antibody
- Background
-
Synonyms: DNMT3A2, TBRS
Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
- Gene ID
- 1788
- UniProt
- Q9Y6K1
-