LIG4 antibody

Catalog No. ABIN6943923

Product Details anti-LIG4 Antibody

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LIG4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human DNA Ligase IV aa 500-700

Clone: 2D9

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for LIG4

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Alternative Name: LIG4 (LIG4 Products)

Synonyms: zgc:165595 antibody, lig4 antibody, DNA LIGASE IV antibody, LIG4 antibody, lig4-A antibody, 5830471N16Rik antibody, tiny antibody, DNL4 antibody, ligase IV, DNA, ATP-dependent antibody, DNA ligase 4 antibody, ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining antibody, DNA ligase IV antibody, ligase IV, DNA, ATP-dependent L homeolog antibody, lig4 antibody, LIG4 antibody, LOC100212302 antibody, CpipJ_CPIJ005161 antibody, PTRG_09982 antibody, MCYG_05151 antibody, LOC657210 antibody, ATLIG4 antibody, lig4.L antibody, Lig4 antibody

Background:

Synonyms: DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4.

Background: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Gene ID: 3981

UniProt: P49917

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response