PARP2 antibody

Catalog No. ABIN6944437

Product Details anti-PARP2 Antibody

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PARP2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within the C-terminus of human PARP2.

Clone: 19A1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PARP2

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Alternative Name: PARP2 (PARP2 Products)

Synonyms: ADPRT2 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD2 antibody, PARP-2 antibody, pADPRT-2 antibody, Adprt2 antibody, Adprtl2 antibody, Aspartl2 antibody, C78626 antibody, cb996 antibody, adprtl2 antibody, ADPRT-2 antibody, APP antibody, ATPARP1 antibody, PARP1 antibody, POLY(ADP-RIBOSE) POLYMERASE antibody, POLY(ADP-RIBOSE) POLYMERASE 1 antibody, PP antibody, T14P8.19 antibody, T14P8_19 antibody, poly(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 2 antibody, poly(ADP-ribose) polymerase 2 antibody, poly (ADP-ribose) polymerase family, member 2 antibody, poly (ADP-ribose) polymerase 2 antibody, poly(ADP-ribose) polymerase 2 S homeolog antibody, poly(ADP-ribose) polymerase antibody, PARP2 antibody, Parp2 antibody, parp2 antibody, parp2.S antibody

Background:

Synonyms: Poly [ADP-ribose] polymerase 2, ADP-ribosyltransferase diphtheria toxin-like 2, NAD(+) ADP-ribosyltransferase 2, Poly[ADP-ribose] synthase 2, PARP-2, hPARP-2, ARTD2, ADPRT-2, pADPRT-2, PARP2, ADPRT2, ADPRTL2

Background: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex

Gene ID: 10038

UniProt: Q9UGN5

Pathways: DNA Damage Repair