Poly (ADP-Ribose) Polymerase 2 (PARP2) antibody

Details for Product No. ABIN6944437
Antigen
  • ADPRT2
  • ADPRTL2
  • ADPRTL3
  • ARTD2
  • PARP-2
  • pADPRT-2
  • Adprt2
  • Adprtl2
  • Aspartl2
  • C78626
  • cb996
  • adprtl2
  • ADPRT-2
  • APP
  • ATPARP1
  • PARP1
  • POLY(ADP-RIBOSE) POLYMERASE
  • POLY(ADP-RIBOSE) POLYMERASE 1
  • PP
  • T14P8.19
  • T14P8_19
  • poly(ADP-ribose) polymerase
  • poly(ADP-ribose) polymerase 2
  • poly(ADP-ribose) polymerase 2
  • poly (ADP-ribose) polymerase family, member 2
  • poly (ADP-ribose) polymerase 2
  • poly(ADP-ribose) polymerase 2 S homeolog
  • poly(ADP-ribose) polymerase
  • PARP2
  • Parp2
  • parp2
  • parp2.S
Reactivity
Human, Mouse (Murine), Rat (Rattus)
83
51
11
4
4
4
4
3
1
1
Host
Rabbit
87
9
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
5
4
4
4
3
2
2
2
2
2
2
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
77
51
10
9
8
8
6
6
2
2
2
1
Options
Immunogen Recombinant protein within the C-terminus of human PARP2.
Clone 19A1
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PARP2 (PARP2 Antibody Abstract)
Background

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex

Subcellular location: Nucleus


Synonyms: Poly [ADP-ribose] polymerase 2, ADP-ribosyltransferase diphtheria toxin-like 2, NAD(+) ADP-ribosyltransferase 2, Poly[ADP-ribose] synthase 2, PARP-2, hPARP-2, ARTD2, ADPRT-2, pADPRT-2, PARP2, ADPRT2, ADPRTL2
Gene ID 10038
UniProt Q9UGN5
Pathways DNA Damage Repair
Application Notes WB(1:500-1000), FCM(1:50-100)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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