CD80 antibody
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- Target See all CD80 Antibodies
- CD80
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Reactivity
- Mouse
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Host
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Armenian Hamster
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Clonality
- Monoclonal
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Conjugate
- This CD80 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
- Purification
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Endotoxin Level
- Low endotoxin: < 0.01 EU/ug
- Clone
- 16-10A1
- Isotype
- IgG
- Top Product
- Discover our top product CD80 Primary Antibody
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- Application Notes
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Comment
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2.0 mg/mL
- Restrictions
- For Research Use only
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- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
- Preservative
- Azide free
- Storage
- 4 °C
- Storage Comment
- 2-8°C
- Expiry Date
- 12 months
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- Target
- CD80
- Alternative Name
- CD80 (B7-1) (CD80 Products)
- Synonyms
- B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody
- Background
- The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co- stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
- Gene ID
- 12519
- UniProt
- Q00609
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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