RAR-alpha (AA 420-443) antibody
Reactivity: Human, Mouse
IHC, SSA, WB
Host: Mouse
Monoclonal
9alpha-9A6
unconjugated
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- Target
- RAR-alpha
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Binding Specificity
- AA 420-443
- Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
- Application
- Immunohistochemistry (IHC), Supershift Assay (SSA), Western Blotting (WB)
- Characteristics
- Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-a (Nuclear receptor subfamily 1 group B member 1, NR1B1) interacts with NCoA3, NCoA6, NCoA7 and MLL to activate transcription of target genes. Chromosomal aberrations of RAR-a are sometimes involved in Promyelocytic leukemia. RAR-alpha antibody (mAb) (Clone 9a-9A6) was raised in a Mouse host. It has been validated for use in Immunohistochemistry, Supershift and Western blot, it has been shown to react with Human and Mouse samples.
- Purification
- Protein A Chromatography
- Immunogen
- This RAR-a antibody was raised against a recombinant protein corresponding to amino acids 420-443 (the F region) of human RARa.
- Clone
- 9alpha-9A6
- Isotype
- IgG1 kappa
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Purified IgG in 60 mM Sodium Citrate, 105 mM Tris-HCl, 30 % glycerol, and 0.035 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- Target
- RAR-alpha
- Alternative Name
- RAR-α
- Molecular Weight
- 52 kDa
- NCBI Accession
- NP_001138773
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