PRKAR2A antibody (AA 1-404)

Catalog No. ABIN6989126

Product Details anti-PRKAR2A Antibody

Target: PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))

Binding Specificity: AA 1-404

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKAR2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: KO-Validated

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-404 of human PRKAR2A (NP_004148.1).

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PRKAR2A

Target: PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))

Alternative Name: PRKAR2A (PRKAR2A Products)

Synonyms: PKR2 antibody, PRKAR2 antibody, prkar2a antibody, zgc:85886 antibody, PRKAR2A antibody, 1110061A24Rik antibody, AI317181 antibody, AI836829 antibody, RII(alpha) antibody, protein kinase cAMP-dependent type II regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha, B antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, protein kinase, cAMP dependent regulatory, type II alpha antibody, protein kinase cAMP-dependent type 2 regulatory subunit alpha antibody, PRKAR2A antibody, prkar2ab antibody, Prkar2a antibody

Background:

Synonyms: PRKAR2A,PKR2,PRKAR2

Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Gene ID: 5576

UniProt: P13861

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection