c-MYC antibody (pThr58)

Catalog No. ABIN6989944

This Rabbit Monoclonal antibody specifically detects c-MYC in WB, FACS and IF (cc). It exhibits reactivity toward Human.

Quick Overview for c-MYC antibody (pThr58) (ABIN6989944)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 60D10

Product Details anti-c-MYC Antibody

Binding Specificity: pThr58

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: c-Myc

Background:

Synonyms: Avian myelocytomatosis viral oncogene homolog antibody, bHLHe39 antibody, c Myc antibody, Class E basic helix-loop-helix protein 39 antibody, MRTL antibody, Myc antibody, Myc protein antibody, Myc proto oncogene protein antibody, Myc proto-oncogene protein antibody, myc related translation/localization regulatory factor antibody, MYC_HUMAN antibody, Myc2 antibody, MYCC antibody, Niard antibody, Nird antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody, v myc avian myelocytomatosis viral oncogene homolog antibody, v myc myelocytomatosis viral oncogene homolog antibody

Background: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].

Gene ID: 4609

UniProt: P01106

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect